This report includes information on the 2021-2022 Study of Family and Staff Experiences in American Indian and Alaska Native Head Start Family and Child Experiences Survey Programs (the 2021-2022 Study). The 2021-2022 Study collected data from children's parents, teachers, center directors, and program directors in Region XI Head Start programs in fall 2021 and spring 2022. The purpose of this report is to (1) provide information about the 2021-2022 Study, including the background, design, methodology (including the impact of the COVID-19 pandemic on data collection), and analytic methods; and (2) report detailed descriptive statistics (averages, response ranges, and percentages) in a series of tables containing information on children, their families, their lead teachers and classrooms, and their centers and programs.