Head Start is a national program that helps young children from families with low incomes prepare to succeed in school. It does this by working to promote their early learning and health and their families' well-being. Head Start connects families with medical, dental, and mental health services to be sure that children are receiving the services they need to develop well. Head Start also involves parents in their children's learning and development and helps parents make progress on their own goals, such as housing stability, continuing education, and financial security (Administration for Children and Families 2020). Head Start programs are organized into 12 regions. Regions I through X are geographically based, and Regions XI and XII are defined by the populations they serve. All Region XI Head Start programs are operated by federally recognized tribes; Region XII encompasses Head Start programs that serve migrant and seasonal workers' children and their families. There are 155 Region XI Head Start programs across the U.S., serving around 17,000 children (U.S. Department of Health and Human Services 2023). Most of the children in these programs (85 percent) are American Indian or Alaska Native (AIAN) (U.S. Department of Health and Human Services 2023). Understanding that communities have unique needs and priorities, Region XI programs also offer a variety of services related to children's home language or Native language and culture. In 2021, the Office of Planning, Research, and Evaluation in the Administration for Children and Families, U.S. Department of Health and Human Services, contracted with Mathematica to design and conduct the 2021-2022 Study of Family and Staff Experiences in American Indian and Alaska Native Head Start Family and Child Experiences Survey Programs (the 2021-2022 Study). Fall 2021 data collection for the 2021-2022 Study occurred during the COVID-19 pandemic and participation and response rates were low. The data in this report provide a window into the experiences of a small number of Region XI children, their families, and their teachers who were able to participate in fall 2021 data collection between November 2021 and January 2022. The data do not represent all Region XI Head Start children, their families, and their teachers nationally. They provide a snapshot of the experiences of children in Region XI Head Start children, their families, and their teachers during this difficult time.