This report includes information on the design and methodology of the 2021-2022 Study of Family and Staff Well-Being in Head Start Family and Child Experiences Survey Programs (the 2021-2022 Study) and presents key findings from the study's spring 2022 data collection with Head Start program directors, center directors, and teachers. The 2021-2022 Study gathered data from three sources in spring 2022 that are presented in this report: (1) A program director survey; (2) A center director survey; and (3) A teacher survey. Staff completed surveys that included questions about their program, center, or classroom, and about themselves. In spring 2022, 180 programs were sampled and 176 agreed to participate in the study. Within those programs, 340 centers and 631 teachers agreed to participate in the study. From those, we received 132 completed program director surveys, 237 completed center director surveys, and 358 completed teacher surveys (with marginal response rates of 75 percent, 70 percent, and 57 percent, respectively). Spring 2022 data collection for the 2021-2022 Study occurred during the COVID-19 pandemic and participation and response rates were low. The data in this report provide a window into the experiences of a sample of Head Start program directors, center directors, and teachers who were able to participate in spring 2022 data collection between April and July 2022. Readers should not assume the data are nationally representative of all Head Start programs, centers, classrooms, or staff. These data provide a snapshot of the experiences of Head Start programs, centers, classrooms, and staff during this difficult time and describe them in spring 2022 as COVID-19 continued to impact the country.