This gender-transformative TVET guideline reflects UNESCO's commitment to an education system that not only equips learners with essential skills for the workforce but also empowers marginalized communities -- particularly women and girls -- through equitable and inclusive learning pathways. The guideline integrates gender-responsive strategies, enabling TVET centres in South Sudan to advance gender equality and climate resilience. By fostering education in science, technology, engineering and mathematics (STEM), green entrepreneurship and gender-sensitive training, TVET institutions can offer valuable avenues for women and youth to contribute to both environmental sustainability and economic prosperity.