This article reviews various models in the neurological conceptualization of attention deficit disorder (ADD), with and without hyperactivity. It discusses neuroanatomical, neurochemical, and neurophysiological perspectives on ADD. (Author/DB)

Reports on the use of PlayDoh clay in a college neuroanatomy class. Describes how students constructed a PlayDoh model of a sheep's brain subsequent to performing a standard dissection procedure. Maintains that students learned from the procedure and recommended the use of the technique in future classes. (CFR)

Analysis of family and medical histories of 5 children (ages 11 to 16) with autism and hyperlexia and 5 sex-matched and IQ-matched children (ages 9 to 15) with autism but no hyperlexia suggested that children with autism and hyperlexia represent part of the continuum of autism rather than a specific syndrome. (Author/DB)

This article summarizes work in progress at the Bowman Gray School of Medicine (North Carolina) on the structure and physiological profiles of reading disability and relates the findings to core left-hemisphere language functions. Data add evidence of the structural anomalies associated with dyslexia and evidence of its heritability, especially of…

This study analyzed the spontaneous speech of eight Israeli children (ages 3-6) with congenital neurological syndromes (NS) and cognitive impairments. Comparison with language-matched controls found no differences on 10 grammatical variables and slight differences on 3 semantic-pragmatic variables. Findings suggest a mechanism functionally akin to…

Discusses the use of new statistical procedures in a study of the enduring effects of prenatal alcohol exposure upon the neurobehavioral development of some 500 children born in 1975-76. Explains how the Partial Least Squares (PLS) methodology can summarize the data powerfully while avoiding familiar inferential pitfalls. (MDM)

Explores the significant findings that have emerged from research about the human brain regarding the importance of creating a brain-compatible learning environment. Presents eight components of a brain-compatible learning environment: absence of threat, meaningful content, choices, adequate time, enriched environment, collaboration, immediate…

Studies of American Sign language including functional magnetic resonance imaging of deaf signers confirms the importance of left hemisphere structures in signed language, but also the contributions of right hemisphere regions to sign language processing. A case study involving cortical stimulation mapping in a deaf signer provides evidence for…

This article proposes a neurobiological account of reading and reading disability suggesting that for normally developing readers, the dorsal (tempo-parietal) circuit predominates at first, and in conjunction with premotor systems, is associated with analytic processing necessary for learning to integrate orthographic with phonological and…

Background: Williams syndrome (WS), a neurodevelopmental disorder, is characterized by pervasive cognitive deficits alongside a relative sparing of auditory perception and cognition. A frequent characteristic of the phenotype is adverse reactions to, and/or fascination with, certain sounds. Previously published reports indicate that people with WS…

Background: Brain morphology and physiological measures in schizophrenia have yielded inconsistent results. This may be due in part to difficulties in ascertaining precisely to what degree each measure deviates from its genetically and environmentally determined potential level. We attempted to surmount this problem in a paradigm involving…

Recent evidence supports a role for genetics in autism, but other findings are difficult to reconcile with a purely genetic cause. Pathological changes in the cerebellum in autism are thought to correspond to an event before 30-32 weeks gestation. Our purpose was to determine whether there is an increased incidence of stressors in autism before…

The possible relation between stuttering and the basal ganglia is discussed. Important clues to the pathophysiology of stuttering are given by conditions known to alleviate dysfluency, like the rhythm effect, chorus speech, and singing. Information regarding pharmacologic trials, lesion studies, brain imaging, genetics, and developmental changes…

Acetylcholine release in sensory neocortex contributes to higher-order sensory function, in part by activating nicotinic acetylcholine receptors (nAChRs). Molecular studies have revealed a bewildering array of nAChR subtypes and cellular actions; however, there is some consensus emerging about the major nAChR subtypes and their functions in…

The Child Development & Behavior (CDB) Branch of the National Institute of Child Health and Human Development (NICHD) seeks to improve the health and well-being of individuals from infancy through early adulthood by supporting research into healthy growth and development, including all aspects of child development. The study of typical child…