Since 1999, the authors have written numerous articles and books, given hundreds of presentations, served on national eLearning groups, and created new international online programs, all while paying careful attention to the trends, issues, and best practices in the effective use of technology tools and distance learning methods. In this article, they share what they have learned about effective practices for online teaching and learning and organizational management of eLearning programs. They believe that whatever the setting, format, or delivery system, effective online teaching and learning needs to be effective, relevant, engaging, enabling, inspiring, empowering, and transformational. These keywords serve as both goals and outcomes in their approaches. They need to bake them into the recipe for online teacher education and professional development so that learners enjoy the fruits of their success. A list of references and resources is included.