There is a perfect storm brewing in post-secondary education (PSE) in Ontario. Four major forces are combining in this storm, an ever growing higher education participation rate, the growing demand for effective and timely knowledge delivery, the need to drastically alter how one views teaching and learning, and accelerated technological changes. These forces are compelling educators to re-think their roles in, and out of the classroom. During the summer of 2012, Glen Murray, the Minister of Training, Colleges and Universities (MTCU), hosted a number of round table discussions with stakeholders from colleges and universities across the province to discuss these critical issues and attempt to formulate a strategy for sustainable change in PSE in Ontario (Ministry of Training, Colleges and Universities [MTCU], 2012). This paper reviews the forces driving the need for change in teaching and learning and presents emergent and existing technologies that may help to transform PSE in Ontario.