Objectives: To identify the substance use and the sexual behaviors of college students with disabilities. Methods: A secondary data analysis was conducted of the spring 2009 administration of the ACHA-NCHA II. Results: College students with disabilities tended to be 24 or more years old; of an ethnic minority; and bisexual, gay, or lesbian. They consistently reported engaging in both substance use and sexual risk behaviors more than those of students without disabilities. Conclusions: Substance use and sexuality programs on college campuses should be physically, socially, and intellectually accessible for students with disabilities while considering their multiple identities. Efforts should be made to recruit or target these students for such programming.