In the United States, an estimated 1.2 million people are living with HIV/AIDS, and approximately 50,000 new cases of HIV are diagnosed each year. Globally, it is estimated that 33.3 million people are living with HIV/AIDS. The role of mobile populations in the spread of STIs and HIV is well-documented in many countries around the world. Long-haul truck drivers in developing countries play a key contributing role in STI/HIV disease transmission. For many global public health programs in other countries, evidence-based practices for HIV/AIDS prevention developed in North America are applied throughout the world. In this article, the researchers suggest applying a reverse approach by translating HIV prevention strategies that have proven effective in the trucker population in other countries to the 3.2 million at risk long-haul truck drivers in the United States. The authors propose implementing HIV education and outreach campaigns in the United States that have been successful in global applications. Strategies such as mobile STI clinics, condom banks and distribution, tailored testing, advertising, peer education, and education and outreach at truck stops and cargo loading areas may prove effective in HIV prevention for this population. Additionally, the utilization of innovative technology methods to provide, for example, intervention education via the Internet; satellite radio may also be beneficial. (Contains 1 table and 1 note.)