This study explores how to make diverse learning/instructional materials compatible with e-readers when the instructor pioneered to adopt e-readers into a course of the graduate level. What problems did the instructor encounter when she used the e-readers as a major tool to deliver learning contents, such as the process of converting the traditional instructional materials into the adequate file formats compatible with e-readers? Was it easy or challenging? What converting tools should be used? What additional efforts were required? To shed light on appropriately adopting e-readers as a learning tool in the classroom, the authors conducted this study on making various instructional materials for those popular e-readers in the market, Kindle and iPad. The study focuses on the following three aspects: (1) the process of learning materials design and file conversion; (2) the efforts and time spent on design; and (3) the principles of digitalizing materials before conversion. This study concludes that it is challenging but feasible to make diverse learning materials compatible with e-readers integrated into a classroom setting given the current situation that instructors often use a variety of learning materials from different resources as indicated in this study. Importantly, the instructor and teaching assistants had tackled the big fundamental issue, the file conversion. However, through this study, some ideal converting tools were identified as a better solution. However, additional time and efforts were required from the instructor and teaching assistants. The results of this study indicate that to make the best use of e-reader, converting to specific formats, EPUB and AZW, is necessary as the critical initial step. However, it is evident that the diversity of layout in the original PDF file makes conversion work time-consuming. To shorten working time, some principles of digitalizing material before conversion are suggested as guidelines: (1) Principle 1: Change multicolumn layout to one-column layout; (2) Principle 2: Delete unnecessary header, footer and page number; (3) Principle 3: Save table and chart as graph; (4) Principle 4: Avoid paragraph and graph display side by side; and (5) Principle 5: Do not use PNG format graph (It will become the black background). (Contains 6 tables.)