This paper provides a design framework for building online teacher professional development communities for preservice and inservice teachers. The framework is based on a comprehensive literature review on the latest technology and epistemology of online community and teacher professional development, comprising four major design factors and three contextual factors. The design factors include learning goals, communication tools, participant structures, and member responsibilities; the contextual factors are culture, politics, and economics. Finally, the role of universities and implications of the design framework for teacher professional development in the new culture of learning are discussed.