Depression and cigarette smoking are recurrent, interacting problems that co-occur at high rates and--especially when depression is chronic--are difficult to treat and associated with costly health consequences. In this paper we present an integrative therapeutic framework for concurrent treatment of these problems based on evidence-based practices and Functional Analytic Psychotherapy (FAP). We report the results of a pilot study in which clients (n = 5) received the integrated treatment. Case material is presented to illustrate the integration of interventions within a FAP framework.