Exertional rhabdomyolysis gained increased attention recently when 13 football players from the University of Iowa developed this condition after an especially demanding practice session and were hospitalized. Exertional rhabdomyolysis may lead to severe kidney stress, kidney failure, and even sudden death. Anyone who does physical exercise at a level beyond their normal training routine is a potential candidate for exertional rhabdomyolysis. Therefore, exercise professionals have an obligation to understand the signs, symptoms, treatment, and prevention recommendations to ensure that those they supervise can exercise in a safe and effective manner. Coaches, physical educators, trainers, and parents need to be aware of the fitness level of their charges and make sure to avoid extreme increases in training volume, especially in a hot and humid environment. (Contains 1 table.)