Adolescent health and health literacy are critical health topics recognized in Healthy People 2020. Evidence indicates that adolescents who are d/Deaf have unique health-related needs, yet health communication efforts have not reached them. Despite the Internet's exponential growth and the growth of online health information-seeking behavior among adolescents, reliable information devoted specifically to d/Deaf adolescents who communicate primarily in ASL is rare. D/deaf adolescent females face numerous challenges accessing web-based health information to enhance their decision making about important health issues such as body image, physical activity and nutrition, puberty, and relationships. A strong need exists for interdisciplinary professionals to investigate the health interests and online health information-seeking behaviors of this group in order to effectively plan, implement, and evaluate a web-based health repository that delivers content in ASL. This "Call to Action" represents a first step in addressing that need.