This study identifies qualities associated with the successful adaptation of families with a husband diagnosed with prostate cancer. Both qualitative and quantitative measures were used in this cross-sectional survey research design. Twenty-one husbands and their spouses independently completed six questionnaires and a biographical questionnaire, and they answered an open-ended question. The qualitative findings revealed the importance of intrafamilial support, spiritual/religious beliefs, and professional support and knowledge, while the quantitative results indicated that family adaptation was fostered by the family's internal strengths and durability, affirmative communication, and the experience of social support. The findings could be used to develop interventions that promote family resilience and affirm the reparative potential of families. (Contains 2 tables.)