Beginning with a reference to living in a time of both uncertainty and opportunity, this article presents a discussion of key areas where shared understanding is needed if we are to successfully realize the design and use of high quality, valid assessments of science. The key areas discussed are: (1) assessment purpose and use, (2) the nature of assessment and the importance of research on learning, (3) assessment design processes, (4) validity arguments, (5) measurement and statistical inference, (6) affordances of technology, and (7) systems of assessment. After introducing each vital area, the article discusses how each of the five articles in the special issue is connected to the areas. Concluding comments emphasize the reminder that despite the large amount of work to be done, we are well positioned to realize the high quality, valid science education assessments that we need for K-16 science education.