The present study investigates in what ways teachers themselves see their significance vis-a-vis their students. Seven hundred fifty-seven teachers (64% females and 36% males) from 59 Israeli schools participated in the study. We found that in general, teachers view "significant teachers" as those that help and assist their students and those that serve as a personal example for them. Some effects of teacher's cultural background, gender, and school roles on their perceptions are reported. Teacher burnout was negatively correlated with the positive characteristics attributed to significant teachers. Implications for teachers and for educational institutions are discussed.