Although evidence-based interventions to reduce underage drinking have been identified, dissemination into "real-world" communities remains challenging. The purpose of this community-based translational research is to test SAMHSA's Strategic Prevention Framework (SPF) as a model for such dissemination and evaluate its effect on alcohol use by youth aged 12-17. From 2001-2009 in Eau Claire, Wisconsin we used the SPF to assess community needs and implement a comprehensive strategy of evidence-based programs targeting youth, parents and the community. Over this time, youth alcohol measures from middle and high school surveys showed an 8.6% decline in past-month alcohol use (p less than 0.05) and a 20.5% decline in ease of obtaining alcohol (p less than 0.05). From 2004 to 2009 there was a 5.8% decrease in binge alcohol use (p less than 0.05) and a 12.0% increase in perceived parental disapproval of alcohol use (p less than 0.05). Based on our findings, the SPF is a promising model for communities seeking to reduce underage drinking. (Contains 4 tables and 3 figures.)