Students with emotion dysregulation have significant difficulty modulating emotional reactions, particularly in response to frustration or challenge. These children can present with a variety of DSM diagnoses in schools, including attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), major depressive disorder (MDD), and bipolar disorder (BD). The authors' previous article examined research advances in understanding emotional dysregulation in youth. Here, the authors focus on practical suggestions for working with these students. Some of their recommendations come from sources that specifically address pediatric bipolar disorder (PBD; a disorder where emotion dysregulation is particularly prominent), whereas others come from research examining effective interventions for children with combined disruptive behavior and mood disorders. The authors conclude that school psychologists who understand how to work with this population of students can foster educational environments that are most likely to facilitate success. Toward this end, school psychologists can: (a) educate parents, educators, and students about emotional dysregulation, its symptoms, and medication side effects; (b) provide behavioral and social skills interventions to students; and (c) serve as liaisons between medical professionals, educational professionals, and families.