This study sought to better understand the cultural meaning of adulthood and disability in a large city in central Mexico. Using an ethnographic case study research design that included interviews and observations, this study addressed the research question: What is the cultural meaning and accompanying challenges of becoming an adult with disability in Cuernavaca, Morelos, Mexico? Results indicate that the adult life of a person with a disability is difficult. Corruption, societal rejection, and inadequate school and social services are challenges this population faces. Analyses also revealed that Wolfensberger's (1972) original depiction of the social roles people with disabilities play in society was still accurate in today's Mexico. Research findings and implications for future study are also discussed.