Objective: This study examines differences in reported levels of drug and alcohol use between college students with and without ADHD. Method: The Michigan Alcohol Screening Test (MAST) and several self-report and interview questions, developed by Barkley, were used to examine the drug and alcohol use of college students with and without ADHD. Results: Between-group differences were found on the MAST and in the endorsement of marijuana use. Subtype differences were also found on the MAST. Several factors, including medication treatment status, ethnicity, class standing, and gender were found to be differentially related to problematic drinking behaviors. Conclusions: Difficulties in self-regulation may put college students with ADHD at a higher risk of problematic drinking and the subsequent risk for alcohol-use disorders than their peers. Possible explanations for results are discussed in terms of theory, prevention efforts, and future research. (Contains 4 tables.)