Using a quasi-experimental design, this study examined the effectiveness of a standardized intervention model designed to build resiliency in children of women with co-occurring mental health and substance use disorders and histories of interpersonal abuse. The children and mothers who participated in this study were a subset of the sample used for the Women, Co-occurring Disorders and Violence Study (WCDVS). The children's intervention model consisted of three components: clinical assessment, service coordination and advocacy, and a psychoeducational skills-building group. Children in the comparison group received individual, group, and family services. Six-month and 12-month outcomes were examined among 253 children. Children in the intervention group improved significantly more than children in the comparison group. (Contains 4 tables and 1 figure.)