This descriptive study employed a within-groups analytic approach to examine patterns of sexual risk behavior and co-occurring general and race/ethnicity-specific risk and protective factors in a community sample of African-American youth (n = 436). Cluster analysis was used to classify young adults by levels of self-reported past year sexual risk behaviors. MANOVA, ANOVA, and chi-square analyses indicated significant associations between cluster membership and (a) lifetime psychiatric diagnoses, (b) peer substance use behaviors, and (c) self-reported past year alcohol and marijuana use. Cluster membership was not associated with several race/ethnicity-specific variables: racial/ethnic orientation, cultural mistrust, and perceived discrimination. The results of the current study can inform the development of HIV/STI prevention strategies for vulnerable African-American youth. (Contains 3 tables.)