This study determined how multiple ecodevelopmental domains influenced dysphoria in a community sample of Latina adolescents. Risk factors tested include childhood maltreatment, parental alcohol-related problems, and polysubstance problems. Protective factors include general self-efficacy, social conformity, and family connection. Female participants ( N = 904) were recruited from the Los Angeles area. Many significant correlations were found between the ecodevelopmental domains and dysphoria. The strongest unique protective factor was family connection; others were social conformity and general self-efficacy. The only unique risk factor that emerged was physical neglect. (Contains 3 tables.)