There is considerable interest in applying Response to Intervention (RtI) as a schoolwide methodology for instruction, assessment, and intervention for students who, early in their academic careers, are struggling academically. Supporters contend that the tiered service delivery model holds great promise for many students who otherwise would fall behind and end up with a disability label. It is unclear whether RtI is compatible with gifted learners, although a number of authorities in the gifted field are advocating for its adoption for all students, including high-ability students. This article provides a rationale for why gifted education should consider RtI assessment protocols compatible with gifted learners, discusses the implications of RtI's core requirements and assessment measures for gifted learners, and offers a model for implementing RtI for gifted learners. (Contains 1 figure and 1 table.)