The authors of this article argue both the urgency and the promise of establishing a constructive conversation among different bodies of research, including science interest, sociocultural studies in science education, and culturally relevant teaching. With the instructional practices of eight exemplary African American elementary teachers serving their investigative site, they begin to develop a theory for promoting student interest in science. They argue that this emerging theory is distinguishable by three broad propositions: having a genuine interest, scaffolding student interest, and offering multiple standpoints. They further show that their theory based on these three related propositions has provided an important framework to better understand a number of important issues in science education (e.g., early interest in science and hands-on science activities). (Contains 1 note, 1 table, and 1 figure.)