An essential understanding about brain-based education is that most neuroscientists don't teach and most teachers don't do research. It's unrealistic to expect neuroscientists to reveal which classroom strategies will work best. That's not appropriate for neuroscientists, and most don't do that. Many critics could cite this as a weakness, but it's not. Neuroscience and many related disciplines (e.g., genetics, chemistry, endocrinology) are what is referred to as basic science. The work is done in labs, and the science is more likely to provide general guidelines or suggest future directions for research. Of all the neuroscience studies published each month, only a small fraction of them have potential educational relevance. Brain-based teaching is the active engagement of practical strategies based on principles derived from brain-related sciences. All teachers use strategies; the difference here is that the strategies used are based on real science, not rumor or mythology. This article discusses how brain-based teaching strategies can enhance one's effectiveness and lower one's stress.