Despite the influx of immigrants in the American workplace, little is known about their well-being. The authors built on literature pertaining to gender-specific stressors and organizational support theory to examine a model of stress for immigrants. Analysis of a national, archival data set (N = 150) demonstrated that, consistent with research involving U.S. citizens, immigrant women reported higher stress than immigrant men. The authors extended the literature, however, by showing that the sex-stress relationship is not straightforward for this population. Specifically, supervisor support moderated the effect of sex such that male-female stress differences were twice as large when supervisors were less supportive. (Contains 1 figure, 2 tables and 2 notes.)