In this article, the authors examine pre-service special education teacher reaction to and experience in a collaboratively taught higher education course. Forty-three full-time postbaccalaureate students participate in a course designed to examine critical issues in special education, taught by two faculty members, one specializing in mild and moderate disabilities and the other in moderate and severe disabilities. Pre-service teachers respond to a survey about their knowledge and comfort with co-teaching. Data are collected and analyzed both quantitatively and qualitatively. Three qualitative themes regarding participants' perceptions of skills affecting co-teaching emerge: interpersonal skills, collaborative skills, and instructional issues. Overall, participant knowledge of co-teaching increase and faculty modeling of co-teaching is reported as the most valuable contributing factor. (Contains 5 tables.)