The arts and sciences have been identified as two specific domains that are dependent upon the creative process. A total of 369 undergraduate students served as research participants in two separate studies. In the first study, participants (N = 238) completed a measure of Openness to Experience (NEO-PI; McCrae & Costa, 1999) and a questionnaire assessing artistic and scientific creativity (ASAS; Guastello & Shissler, 1994). Results from study 1 indicated that the Aesthetics and Actions personality traits were significantly related to artistic creativity, while the Ideas trait was the only lower level personality trait to significantly correlate with scientific creativity. In the second study, participants (N = 131) completed a measure of Openness to Experience (NEO-PI), Vocational Interests (Holland, 1985), and an artistic and scientific creativity questionnaire (Guastello & Shissler, 1994). Findings from study 1 were largely replicated in study 2. Namely, Aesthetics and Ideas were significantly related with artistic and scientific creativity, respectively. Results from partial correlation computations were used to identify specific personality traits that were used in a series of regression models testing the second goal of the second study. Specifically, vocational interests were observed to mediate the relationship between personality dispositions and creativity. Results suggest the ability of lower level personality traits of Openness to differentiate between artistic and scientific creativity. In addition, results lend support for the motivational aspect of vocational interests. (Contains 4 tables.)