The rapid growth of the HIV epidemic in China has raised a number of concerns among health care providers, governmental agencies, and nongovernmental organizations (NGOs). This article (a) briefly discusses the HIV epidemic in China, (b) explains why Chinese NGOs need to join the fight against the epidemic, (c) describes the development of an indigenous culture-based model for use by NGOs to prevent HIV among injection drug users, and (d) discusses a Chinese NGO's experience in piloting the model. Data from the pilot study indicate that the model was successful in increasing knowledge about HIV/AIDS, increasing condom use, and decreasing needle and syringe sharing among a sample of female injection drug users (n = 100). The results of this study could have potential for other NGOs that are interested in adopting and adapting this model for HIV prevention.