Despite an outgrowth in research examining associations between religiosity and health outcomes, there has been a lack of empirical focus on the relationship between religiosity and adjustment to chronic pain. This study investigated specific secular coping strategies that mediate the proposed relationship between religious appraisals and pain-related outcomes. Twenty-nine chronic pain patients completed measures assessing pain-related coping strategies, pain severity, disability, depression, positive and negative affect, trait anger and three types of religious appraisals--benevolent God appraisals, punishing God appraisals, and demonic appraisals. A significant positive relationship was found between punishing God appraisals and depression, with catastrophizing mediating this relationship. Demonic appraisals were significantly related to disability. Benevolent religious appraisals were related to positive affect. Benevolent religious appraisals were significantly related to the secular coping strategies of diverting attention, ignoring pain sensations, reinterpreting pain sensations and using coping self-statements, but these coping strategies did not mediate the relationship between benevolent religious appraisals and positive affect. While this study provides no evidence that religious appraisals influence pain perception, data suggest that both positive and negative religious appraisals are related to mental health outcomes in a chronic pain population.