In the past three decades, mentoring has become a formal and informal vehicle for empowering individuals in both educational and corporate environments. Colleges and universities have established mentoring programs similar to those in the corporate sector to retain students and contribute to their academic and future success. More recently, mentoring programs for female university students and alumnae have appeared as academia has recognized the importance of enhancing mentoring and networking opportunities for women graduates and current students and the benefits derived from such alliances. This article is based on a case study conducted by the author at a Midwestern research university. It describes the creation of an alumnae mentoring program, as well as the program's membership, structure, challenges, outcomes, and value. The paper also raises a number of issues relevant to the development of alumnae mentoring programs and provides specific recommendations for advancement practitioners interested in creating similar programming on their campuses.