This paper is written from the perspective of two postsecondary students who realized the implications for brain-based learning in the online environment. This paper explores the relationship between online learning in regards to how the brain generates meaning and understanding, the role of emotions, the collaborative construction of knowledge, and aspects of neuroplasticity. Throughout the paper, we have made a variety of connections in regards to our experiences with online learning. Finally a brief critique ensues pertaining to the theory of brain-based learning.