Little has been written on the personal experience of the researcher as it relates to data collection, data analysis and interpretation of results. Even more scarce has been knowledge that addresses the challenges and barriers faced by 21st century researchers engaged in ethnographic data collection amidst culturally diverse populations. The present work has addressed these gaps in the literature by detailing the personal, methodological and cultural challenges encountered by this researcher in a larger study which utilized a mixed method design to investigate homeless street youth in Addis Ababa, Ethiopia. Results indicated the need for social workers to possess an awareness of their own limitations and biases as it may relate to cultural differences. (Contains 1 figure.)