The increasing prevalence of self-injurious behavior (SIB) among mainstream adolescents has led to a growing body of research. This maladaptive behavior is used as a means of regulating negative emotions. Best practices regarding therapy are unclear, with many types of intervention being tried. Analysis of 36 qualitative and quantitative studies, reviews, and theory articles addressing adolescent SIB was conducted looking at aspects such as history, demographics, motivators, risk factors, techniques, and treatment options. An explosion of research is surfacing to determine effective care through creative approaches. Dialectical Behavior Therapy (DBT) shows great promise. The school setting is a natural environment for the identification and intervention of SIB which requires knowledge of indicators and risk factors. Education of school staff will increase awareness and enhance communication among disciplines. A circle of care can then surround the student to provide support and guidance while the proper interventions for emotional regulation and individual health promotion are developed.