This article examines the current state of the global fight against cancer and of noncommunicable disease in general, the progress to date against cancer, and postulates that there has never been a more challenging--nor more ideal--time to succeed in making significant headway against the disease worldwide. Based on progress made particularly in the past two decades, and with proven interventions and scientific knowledge, it is possible to bring cancer as a major health problem worldwide under control in this century. The article also discusses what the American Cancer Society, the nation's largest voluntary health organization dedicated to saving lives from cancer, is doing to lead a global movement in support of achieving this goal. (Contains 3 figures.)