This study examines the relationship between sexual experience and various drinking measures in 550 incoming first-year college females. During this transition period, sexually experienced participants reported stronger alcohol expectancies and endorsed higher drinking motives, and drank more frequently and in greater quantities than sexually inexperienced participants. Sexual status was also a significant predictor of alcohol-related nonsexual consequences, over and above amount consumed. Furthermore, controlling for drinking, sexual status moderated the relationship between coping motives and consequences. Among women who endorsed strong coping motives for drinking, sexual experience was linked to greater nonsexual alcohol-related consequences. Implications for prevention and intervention are discussed. (Contains 2 tables and 1 figure.)