The emerging field of nanotechnology has created a new frontier for the convergence of university and industrial research. In the United States, major federal investments provided a massive boom for this field over the decade. This paper reports on a case study of how the University at Albany came to establish the first college of nanotechnology in the US, as part of a larger R&D complex oriented towards building a regional nanoelectronics cluster. The case points to the role of entrepreneurs in mobilizing ideas and resources to advance novel organizational forms. This study demonstrates how a mode of technology transfer based on research facilities was deliberately used to build a nanotechnology complex at Albany, highlighting the enabling role of state S&T policies in supporting university engagements in regional economic development. (Contains 2 figures and 18 footnotes.)