This paper discusses the key findings of an investigation of e-learning computer systems and the establishment of a technology framework for a new generation of e-learning applications. The paper initially reviews an e-learning system case study (a core university and a number of associated institutions named Global Campus) which incorporates: (i) the infrastructure of the Global Campus programme reviewed in light of studies on attitudes towards learning, patterns of Virtual Learning Environment (VLE) use, computer-assisted assessment and learning tasks and patterns of communication, and (ii) an e-learning environment based on the WebCT technology for delivery and assessment. Results of four earlier studies regarding (i) distance education, (ii) patterns of use of the VLE (iii) communication patterns in e-learning and (iv) computer-assisted assessment are also critically reviewed. Conclusively, a set of guidelines for a technology framework are suggested and the authors' perspectives for the classification and the evolution of e-learning applications is provided.