Two specific sources of stress at work have recently received increasing attention in organizational stress research: emotional dissonance (ED) and self-control demands (SCDs). Both theoretical arguments and experimental findings in basic research strongly suggest that ED and different SCDs draw on a common limited regulatory resource. Consequently, both kinds of stressors should exert interactive effects on indicators of job strain and well-being. Drawing on two German samples (total N = 586), we tested this prediction by examining the interaction effects of ED and different dimensions of SCDs on burnout, anxiety, and absence behavior. Latent moderated structural equation modeling provided support for the hypothesized interactive effects of ED and dimensions of SCDs in predicting burnout, anxiety, and absence behavior. More specifically, with each pair of stressors the effects of one stressor were found to be amplified by the other. Finally, we discuss theoretical and practical implications of our results. (Contains 3 figures and 4 tables.)