In this column, the author describes a current research project on vocabulary instruction in settings with high percentages of English learners (EL). The project focuses on designing and implementing a multifaceted, comprehensive vocabulary instructional program (MCVIP) in mixed EL and native English speaker (NES) classrooms in relatively high-poverty schools. The author presents the instructional components of MCVIP, discusses early findings from the project, and encourages teachers and schools to reflect on how the MCVIP approach might inform their own instruction. (Contains 1 figure.)