Historically, the assistive technology (AT) industry is made up of small to medium size companies serving relatively small markets with products characterized as "niche" or "orphan" products. Presenting opportunities to AT companies that are created by outside sources is difficult. Presenting such opportunities to companies serving larger markets is even more difficult. In both cases, transferring new or improved products is fraught with barriers. This paper outlines the critical barriers to brokering efforts between major U.S. university technology transfer offices and U.S. corporations. This paper also identifies the corresponding carriers, or facilitators, and standard practices that are employed to overcome these barriers in both the AT and mainstream markets. The barriers identified in this paper will span the research, development, and commercialization continuum for technology transfer. Over the past 14 years, by using the carriers and standard practices delineated in this paper, the authors have successfully transferred new technologies and devices in the areas of AT and mainstream consumer products. (Contains 2 figures.)