This study explored the perceptions of 395 participants (students, teachers, and education officers) in Ghana on the role of the computer and the teacher in promoting the first five principles of instruction for quality teaching and learning. To achieve the intention of the study, five point Likert-type scales based on the first five principles of instruction, with Cronbach alpha of 0.87, were used for the data collection. Frequency distributions and chi-square tests were employed to analyse the data. The results of the study indicate that there is perception dissimilarities among the participants on the role of a computer and a teacher in implementing the first five principles of instruction. In addition, according to the findings, there is a mismatch of participants' recommendations on training students to acquire computer skills, and training teachers to acquire skills in designing their teaching. The theoretical and practical implications of the results are discussed. (Contains 3 figures and 3 tables.)