Psychology has neglected the study of variation across cities. An urban psychology is needed that takes seriously such variation and focuses on strengths and assets contributing to the good life as much as on problems of urbanization. To illustrate the value of an urban psychology, we describe studies of character strengths among residents in the 50 largest U.S. cities (N = 47,369). Differences in character strengths were found to exist across cities, were robustly related to important city-level outcomes such as entrepreneurship and 2008 presidential election voting, and were associated in theoretically predicted ways with city-level features. We propose a framework that distinguishes between strengths of the "head," which are intellectual and self-oriented, and strengths of the "heart," which are emotional and interpersonal. Cities whose residents had higher levels of head strengths were those rated as creative and innovative. Head strengths predicted the likelihood of a city voting for Barack Obama, whereas heart strengths predicted voting for John McCain. More than half of the world's population now resides in cities, and urban psychology deserves greater attention. (Contains 1 footnote, 1 table, and 2 figures.)