Web sites about sexual health lack the interactivity, humor, and "viral" nature required to attract young adults. The Midwest Teen Sex Show (www.midwestteensexshow.com) is an interactive, humor-based Web site that provides sexual health information to young adults. One episode from the Web site was shown to six focus groups of young women, ages 18-30. Women found it funny, but some were offended or confused. Women were unable to differentiate between facts and humor; however, women could identify the key messages. Most women reported they would think about it later, visit the Web site, and share it with friends. Web-based interventions should use humor with caution.