The purpose of this explanatory case study using critical theory as a philosophical lens was to focus on two science teacher candidates' understandings of Otherness and their culturally responsive teaching (or the lack thereof) of students they believe are the "Others". The researchers found that even though the participants had different goals for their students, they were not responsive to some of their students because of the students" culture, race, and/or ethnicity. Both of the participants believed their science teacher education program had shortcomings and did not provide all of the needed experiences for them to be successful in their science teaching of the "Other" students.