The relationship between drug use and sexual aggression in a sample of men was examined at five time points from adolescence through the 4th year of college. Hierarchical linear modeling explored the relationship between proximal drug use and severity of sexual aggression after controlling for proximal alcohol use at each time period. Results revealed that proximal drug use was associated with sexual aggression severity: Increased drug use predicted increased severity of sexual aggression across time. A second set of analyses explored the relationship between distal marijuana use and severity of sexual aggression after controlling for distal alcohol use. Results indicated that increased marijuana use predicted increased severity of sexual aggression across time. A third set of analyses explored the relationship between distal use of other illicit drugs and severity of sexual aggression after controlling for distal alcohol use. Results mirrored those of the second set of analyses and are discussed in terms of drug use as a component of deviant lifestyles that may include sexually aggressive behavior, including implications for applied settings. (Contains 1 table and 9 notes.)