Although many educational practices are being modified to meet the needs of all learners within elementary schools, there is a paucity of research and resources that explore the essential knowledge base and application of response to intervention within secondary settings. The purpose of this investigation was to explore (a) how important high school principals perceived response to intervention practices to be within secondary settings, and (b) if such practices currently were available within their respective school. Although exploratory in nature, the results of a nationally distributed survey indicated that high school principals perceive response to intervention to be important within their schools, but would require significant and complex change. Recommendations for future research are discussed. (Contains 2 tables.)