The main goal of this study was to investigate whether the use of an individualized approach through microscale chemistry experiments in secondary schools can increase students' understanding of chemistry concepts, improve attitude towards chemistry practical work and motivation. Two comparable groups of Form Four students (16 years old) participated. The students in the experimental group (83) worked individually on ten microscale chemistry experiments, whereas the control group (87) worked in groups on traditional experiments both for a period of 8 weeks. Pre and post tests were conducted before and after the treatment for both groups. Teacher and student perceptions of microscale experimentation are also reported. Findings showed that the microscale approach can increase understanding of chemistry concepts, however, there was no significant difference in attitude and motivation among the students. Teachers and students both had a positive view of microscale experiments. (Contains 8 tables and 1 figure.)